dc.contributor.author | Etli, Mustafa | |
dc.contributor.author | Karahan, Oğuz | |
dc.contributor.author | Akkaya, Özgür | |
dc.contributor.author | Savaş, Hasan Basri | |
dc.date.accessioned | 2022-09-12T10:38:04Z | |
dc.date.available | 2022-09-12T10:38:04Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12868/1585 | |
dc.description.abstract | ABSTRACT
Background: In this study, we aimed to investigate the effects of
cilostazol on angiogenesis and oxidative stress using the chorioallantoic
membrane model.
Methods: In this experimental study, the Ross 308 chick embryos were
used. The negative control group (n=10) received no intervention. The
positive control group (n=10) consisted of eggs treated with epidermal
growth factor for inducing angiogenesis. Three cilostazol groups were
designed with 10-7 (n=10), 10-6 (n=10), and 10-5 (n=10) M concentrations.
Each egg was punctured on the sixth day of incubation, and drug
pellets were introduced to the positive control and drug groups at the
prespecified doses. Vascular development was evaluated on the eighth
day of application. The total oxidant status, total antioxidant capacity,
and oxidative stress index levels were determined from albumen liquids
obtained with a syringe before and after drug application.
Results: Lower oxidative stress index levels were obtained from
the positive control and cilostazol groups compared to the negative
control albumens (p=0.001). The increments in vascular junctions and
newly developed vascular nodules were evaluated in drug-free and
drug-applied chorioallantoic membranes. The highest activity was
obtained in the 10-7 M concentration cilostazol group. An increased
angiogenic activity was detected in all drug groups in each concentration
compared to the negative control group (p=0.001). Angiogenic activity
was similar in all the cilostazol-treated groups (p=0.43).
Conclusion: Cilostazol has a positive stimulant effect on angiogenesis
and it seems to suppress oxidative stress during embryonic growth.
Cilostazol exerts these effects significantly and similarly at different
doses | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | http://dx.doi.org/doi: 10.5606/tgkdc.dergisi.2021.22212 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Angiogenesis | en_US |
dc.subject | Chorioallantoic membrane model | en_US |
dc.subject | Oxidative stress | en_US |
dc.title | Cilostazol induces angiogenesis and regulates oxidative stress in a dose-dependent manner: A chorioallantoic membrane study | en_US |
dc.type | article | en_US |
dc.contributor.department | ALKÜ, Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 449 | en_US |
dc.identifier.endpage | 456 | en_US |
dc.relation.journal | Turkish Journal of Thoracic and Cardiovascular Surgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |